Results

IWC workflow benchmark

Workflow-level bioinformatics tasks derived from IWC

Each item publishes the complete agent query, its source IWC workflow and tool count, the acc evaluator, the step-score rubric, all model results, and an explanation for every score below 1.000. A below-full score may reflect an allowed method difference, numerical precision, or a genuine output problem.

Token usage and cost Open score explanations Multi-step analysis tasks (in progress)
240 results240 numeric acc10 items

GPT-5.5

Open-ended code0.882mean acc
Galaxy-API code0.985mean acc

GPT-5.6 Sol

Open-ended code0.989mean acc
Galaxy-API code0.991mean acc

GPT-5.6 Luna

Open-ended code0.984mean acc
Galaxy-API code0.985mean acc

Codex + DeepSeek V4 Pro

Open-ended code0.959mean acc
Galaxy-API code0.999mean acc

Items

Each cell shows mean acc; earlier dataset results also retain their recorded step scores. Tool-step counts include nested subworkflows; repeated uses count separately. All 240 results have numeric acc. Open an item for all six replicates per model and the complete benchmark specification.

001

Short-read quality control and trimming (SRR1553606)

Short-read quality control and trimming

2 tool steps · 2 unique tools

ModelOpen-ended code mean acc / step scoreGalaxy-API code mean acc / step score
GPT-5.51.000 / 1.0001.000 / 1.000
GPT-5.6 Sol1.000 / 1.0001.000 / 1.000
GPT-5.6 Luna1.000 / 1.0000.998 / 1.000
Codex + DeepSeek V4 Pro0.999 / 1.0000.998 / 1.000
Open item

002

RNA-Seq Differential Expression Analysis

RNA-Seq Differential Expression Analysis with Visualization

17 tool steps · 13 unique tools

ModelOpen-ended code mean acc / step scoreGalaxy-API code mean acc / step score
GPT-5.51.000 / 1.0001.000 / 1.000
GPT-5.6 Sol1.000 / 1.0001.000 / 1.000
GPT-5.6 Luna1.000 / 1.0000.998 / 1.000
Codex + DeepSeek V4 Pro1.000 / 1.0001.000 / 1.000
Open item

003

Host-reference filtering of paired reads (SRR12665180)

Host or Contamination Removal on Short-Reads

2 tool steps · 2 unique tools

ModelOpen-ended code mean acc / step scoreGalaxy-API code mean acc / step score
GPT-5.50.999 / 1.0001.000 / 1.000
GPT-5.6 Sol1.000 / 1.0001.000 / 1.000
GPT-5.6 Luna1.000 / 1.0001.000 / 1.000
Codex + DeepSeek V4 Pro1.000 / 1.0001.000 / 1.000
Open item

005

Paired-End Amplicon Denoising

Dada2: amplicon analysis for paired end data

14 tool steps · 11 unique tools

ModelOpen-ended code mean acc / step scoreGalaxy-API code mean acc / step score
GPT-5.50.300 / 1.0000.931 / 1.000
GPT-5.6 Sol0.951 / 1.0000.954 / 1.000
GPT-5.6 Luna0.958 / 1.0000.950 / 1.000
Codex + DeepSeek V4 Pro0.978 / 1.0001.000 / 1.000
Open item

006

ATAC-seq Chromatin Accessibility Profiling

ATAC-seq Analysis: Chromatin Accessibility Profiling

27 tool steps · 21 unique tools

ModelOpen-ended code mean acc / step scoreGalaxy-API code mean acc / step score
GPT-5.50.995 / 1.0000.999 / 1.000
GPT-5.6 Sol0.970 / 1.0000.997 / 1.000
GPT-5.6 Luna1.000 / 1.0000.996 / 1.000
Codex + DeepSeek V4 Pro0.997 / 1.0001.000 / 1.000
Open item

008

Antimicrobial Resistance Determinant Detection

AMR Gene Detection

7 tool steps · 7 unique tools

ModelOpen-ended code mean acc / step scoreGalaxy-API code mean acc / step score
GPT-5.51.000 / 1.0001.000 / 1.000
GPT-5.6 Sol1.000 / 1.0001.000 / 1.000
GPT-5.6 Luna1.000 / 1.0001.000 / 1.000
Codex + DeepSeek V4 Pro1.000 / 1.0001.000 / 1.000
Open item

009

Clinical Metaproteomics Peptide Verification

Clinical Metaproteomics Verification Workflow

17 tool steps · 10 unique tools

ModelOpen-ended code mean acc / step scoreGalaxy-API code mean acc / step score
GPT-5.50.892 / 1.0000.958 / 1.000
GPT-5.6 Sol0.977 / 1.0000.958 / 1.000
GPT-5.6 Luna0.891 / 1.0000.917 / 1.000
Codex + DeepSeek V4 Pro0.962 / —0.994 / —
Open item

010

Single-Cell Pseudobulk Aggregation

Single-Cell Pseudobulk Differential Expression Analysis with edgeR

13 tool steps · 10 unique tools

ModelOpen-ended code mean acc / step scoreGalaxy-API code mean acc / step score
GPT-5.50.975 / 1.0000.992 / 1.000
GPT-5.6 Sol0.999 / 1.0000.999 / 1.000
GPT-5.6 Luna1.000 / 1.0001.000 / 1.000
Codex + DeepSeek V4 Pro0.666 / 1.0001.000 / 1.000
Open item

011

BioProject Metadata and Sequence Retrieval

Metadata and Sequences from BioProject IDs

10 tool steps · 8 unique tools

ModelOpen-ended code mean acc / step scoreGalaxy-API code mean acc / step score
GPT-5.51.000 / 1.0001.000 / 1.000
GPT-5.6 Sol1.000 / 1.0001.000 / 1.000
GPT-5.6 Luna1.000 / 1.0001.000 / 1.000
Codex + DeepSeek V4 Pro1.000 / 1.0001.000 / 1.000
Open item

Data updated 2026-10-26T14:00:00+00:00.