bix-37-q1 | Current BixBench results

New token-optimization experiment

Three additional GPT-5.6 Sol Galaxy replicates are available separately. Previous results remain unchanged.

View the October 2026 batch and its run records

Question

Based on the proteomics data, what is the fold change in ENO1 protein abundance between tumor and normal samples?

Accepted answer: 4.81-fold increase in tumor
Domain: general

Comparison

Pass counts and token totals across the same three replicates.

Agent	Galaxy-API code	Open-ended code
Codex GPT-5.5	3/3 replicate 1 replicate 2 replicate 3 2.64M total	3/3 replicate 1 replicate 2 replicate 3 336.1K total
Codex GPT-5.6 Sol	3/3 replicate 1 replicate 2 replicate 3 4.01M total	3/3 replicate 1 replicate 2 replicate 3 392.4K total
Codex GPT-5.6 Luna	3/3 replicate 1 replicate 2 replicate 3 8.63M total	3/3 replicate 1 replicate 2 replicate 3 320.7K total
DeepSeek V4 Pro via Codex	3/3 replicate 1 replicate 2 replicate 3 3.00M total	3/3 replicate 1 replicate 2 replicate 3 500.9K total
DeepSeek V4 Pro via Claude Codesuperseded	3/3 replicate 1 replicate 2 replicate 3 2.47M total	3/3 replicate 1 replicate 2 replicate 3 505.8K total

Execution condition

Galaxy-API code with skills

Codex GPT-5.5

3 primary replicates

Codex GPT-5.5

replicate 1

pass

Answer4.81

Workflow

Excel to tabularMatch rowsAdd derived columnSelect columns

Total tokens: 1.11M
Output: 7.5K

Galaxy history Run trace

Codex GPT-5.5

replicate 2

passUDT-only

Answer4.81

Workflow

Galaxy UDTfold-change calculation

Total tokens: 620.6K
Output: 6.2K

Galaxy history Run trace

Codex GPT-5.5

replicate 3

pass

Answer4.81

Workflow

Excel to tabularFilter Tabular

Total tokens: 906.7K
Output: 5.6K

Galaxy history Run trace

Codex GPT-5.6 Sol

3 primary replicates

Codex GPT-5.6 Sol

replicate 1

pass

Answer4.806639812230691

Workflow

Excel to tabularFilter TabularAdd derived column

Total tokens: 1.64M
Output: 7.6K

Galaxy history Run trace

Codex GPT-5.6 Sol

replicate 2

pass

Answer4.81

Workflow

Excel to tabularAdd derived columnfold-change calculation

Total tokens: 984.7K
Output: 7.1K

Galaxy history Run trace

Codex GPT-5.6 Sol

replicate 3

pass

Answer4.81

Workflow

Excel to tabularFilter TabularMatch rowsfold-change calculation

Total tokens: 1.39M
Output: 6.7K

Galaxy history Run trace

Codex GPT-5.6 Luna

3 primary replicates

Codex GPT-5.6 Luna

replicate 1

pass

Answer4.81

Workflow

Excel to tabularFilter TabularTp Grep Tool

Total tokens: 3.29M
Output: 16.9K

Galaxy history Run trace

Codex GPT-5.6 Luna

replicate 2

pass

Answer4.81

Workflow

Excel to tabularFilter TabularTp Grep Tool

Total tokens: 2.67M
Output: 12.3K

Galaxy history Run trace

Codex GPT-5.6 Luna

replicate 3

pass

Answer4.81

Workflow

Excel to tabularFilter Tabular

Total tokens: 2.67M
Output: 14.9K

Galaxy history Run trace

DeepSeek V4 Pro via Codex

3 primary replicates

DeepSeek V4 Pro via Codex

replicate 1

pass

Answer4.81

Workflow

Excel to tabularFilter TabularFilter rows

Total tokens: 977.2K
Output: 10.8K

Galaxy history Run trace

DeepSeek V4 Pro via Codex

replicate 2

pass

Answer4.81

Workflow

Excel to tabularFilter TabularMatch rowsSelect columns

Total tokens: 969.5K
Output: 10.4K

Galaxy history Run trace

DeepSeek V4 Pro via Codex

replicate 3

pass

Answer4.81

Workflow

Excel to tabularFilter TabularMatch rowsSelect columns

Total tokens: 1.06M
Output: 10.9K

Galaxy history Run trace

DeepSeek V4 Pro via Claude CodeSuperseded

3 primary replicates

DeepSeek V4 Pro via Claude Code

replicate 1

pass

Answer4.81

Workflow

Excel to tabularFilter Tabular

Total tokens: 1.21M
Output: 13.1K

Galaxy history Run trace

DeepSeek V4 Pro via Claude Code

replicate 2

pass

Answer4.81

Workflow

Excel to tabular

Total tokens: 418.9K
Output: 4.0K

Galaxy history Run trace

DeepSeek V4 Pro via Claude Code

replicate 3

pass

Answer4.81

Workflow

Excel to tabularFilter rowsfold-change calculation

Total tokens: 840.7K
Output: 6.0K

Galaxy history Run trace

Execution condition

Open-ended code with skills

Codex GPT-5.5

3 primary replicates

Codex GPT-5.5

replicate 1

pass

Answer4.81

Workflow

Local analysisfold-change calculation

Total tokens: 85.5K
Output: 1.4K

Run trace

Codex GPT-5.5

replicate 2

pass

Answer4.81

Workflow

Local analysis

Total tokens: 125.0K
Output: 1.6K

Run trace

Codex GPT-5.5

replicate 3

pass

Answer4.81

Workflow

Local analysis

Total tokens: 125.6K
Output: 1.7K

Run trace

Codex GPT-5.6 Sol

3 primary replicates

Codex GPT-5.6 Sol

replicate 1

pass

Answer4.81

Workflow

Local analysis

Total tokens: 99.6K
Output: 1.1K

Run trace

Codex GPT-5.6 Sol

replicate 2

pass

Answer4.81

Workflow

Local analysis

Total tokens: 164.0K
Output: 1.5K

Run trace

Codex GPT-5.6 Sol

replicate 3

pass

Answer4.81

Workflow

Local analysis

Total tokens: 128.7K
Output: 1.3K

Run trace

Codex GPT-5.6 Luna

3 primary replicates

Codex GPT-5.6 Luna

replicate 1

pass

Answer4.81

Workflow

Local analysis

Total tokens: 102.6K
Output: 1.9K

Run trace

Codex GPT-5.6 Luna

replicate 2

pass

Answer4.81

Workflow

Local analysis

Total tokens: 119.0K
Output: 2.0K

Run trace

Codex GPT-5.6 Luna

replicate 3

pass

Answer4.81

Workflow

Local analysis

Total tokens: 99.0K
Output: 1.7K

Run trace

DeepSeek V4 Pro via Codex

3 primary replicates

DeepSeek V4 Pro via Codex

replicate 1

pass

Answer4.81

Workflow

Local analysisfold-change calculation

Total tokens: 112.3K
Output: 2.8K

Run trace

DeepSeek V4 Pro via Codex

replicate 2

pass

Answer4.81

Workflow

Local analysis

Total tokens: 174.9K
Output: 3.9K

Run trace

DeepSeek V4 Pro via Codex

replicate 3

pass

Answer4.81

Workflow

Local analysis

Total tokens: 213.7K
Output: 5.1K

Run trace

DeepSeek V4 Pro via Claude CodeSuperseded

3 primary replicates

DeepSeek V4 Pro via Claude Code

replicate 1

pass

Answer4.81

Workflow

Local analysisfold-change calculation

Total tokens: 246.3K
Output: 2.0K

Run trace

DeepSeek V4 Pro via Claude Code

replicate 2

pass

Answer4.81

Workflow

Local analysis

Total tokens: 141.6K
Output: 1.2K

Run trace

DeepSeek V4 Pro via Claude Code

replicate 3

pass

Answer4.81

Workflow

Local analysisfold-change calculation

Total tokens: 117.9K
Output: 1.1K

Run trace

bix-37-q1 · October 2026 · three additional replicates

GPT-5.6 Sol · token optimization

Galaxy-API code, high reasoning, Fast service. Previous runs are retained above.

Galaxy-API code · October 2026

replicate 1

Correct

Answer4.80663981223069

Total tokens: 622.4K
Input: 616.6K
Cached input: 580.6K
Output: 5.9K

Run trace Final answer Galaxy history

Galaxy-API code · October 2026

replicate 2

Correct

Answer4.81

Total tokens: 524.3K
Input: 518.7K
Cached input: 490.0K
Output: 5.6K

Run trace Final answer Galaxy history

Galaxy-API code · October 2026

replicate 3

Correct

Answer4.81

Total tokens: 560.9K
Input: 555.9K
Cached input: 526.0K
Output: 5.0K

Run trace Final answer Galaxy history

Open-ended code averaged 0.13M tokens; previous website Galaxy averaged 1.34M; the new Galaxy runs averaged 0.57M, or 4.35× Open-ended code. Each mean covers three replicates of this same task with GPT-5.6 Sol.

Cached input is already included in input tokens. Full nested tool/job evidence is in each HF run's galaxy_execution_records.tar.gz, with an accompanying member index.

Optimization overview and all 150 runs