BixBench current item

bix-30-q3

Question

What is the ratio of significant (p <= 0.05) differentially expressed miRNAs between patient and control groups identified following Bonferroni correction compared to Benjamini-Yekutieli correction? Provide your answer as a ratio in the format "Bonferroni:Benjamini-Yekutieli".

Accepted answer
0:0
Domain
transcriptomics

Comparison

Pass counts and token totals across the same three replicates.

AgentGalaxy-API codeOpen-ended code
Codex GPT-5.53/3
replicate 1 replicate 2 replicate 3
5.56M total
2/3
replicate 1 replicate 2 replicate 3
896.1K total
Codex GPT-5.6 Sol3/3
replicate 1 replicate 2 replicate 3
9.42M total
0/3
replicate 1 replicate 2 replicate 3
1.67M total
Codex GPT-5.6 Luna3/3
replicate 1 replicate 2 replicate 3
13.90M total
2/3
replicate 1 replicate 2 replicate 3
4.78M total
DeepSeek V4 Pro via Codex1/3
replicate 1 replicate 2 replicate 3
21.75M total
0/3
replicate 1 replicate 2 replicate 3
4.54M total
DeepSeek V4 Pro via Claude Codesuperseded3/3
replicate 1 replicate 2 replicate 3
8.15M total
2/3
replicate 1 replicate 2 replicate 3
1.79M total

Execution condition

Galaxy-API code with skills

Codex GPT-5.5

3 primary replicates
Codex GPT-5.5

replicate 1

passUDT-only
Answer0:0
Workflow
Galaxy UDTmean summary
Total tokens
1.52M
Output
10.1K
Codex GPT-5.5

replicate 2

passUDT-only
Answer0:0
Workflow
Galaxy UDTSciPystatsmodelsedgeRDESeq2
Total tokens
2.78M
Output
11.6K
Codex GPT-5.5

replicate 3

passUDT + standard tools
Answer0:0
Workflow
Excel to tabularGalaxy UDTmean summary
Total tokens
1.27M
Output
10.6K

Codex GPT-5.6 Sol

3 primary replicates
Codex GPT-5.6 Sol

replicate 1

passUDT + standard tools
Answer0:0
Workflow
Excel to tabularUnivariateGalaxy UDT
Total tokens
3.06M
Output
14.1K
Codex GPT-5.6 Sol

replicate 2

pass
Answer0:0
Workflow
Excel to tabularUnivariate
Total tokens
3.30M
Output
12.8K
Codex GPT-5.6 Sol

replicate 3

passUDT + standard tools
Answer0:0
Workflow
Excel to tabularUnivariateGalaxy UDT
Total tokens
3.06M
Output
18.8K

Codex GPT-5.6 Luna

3 primary replicates
Codex GPT-5.6 Luna

replicate 1

passUDT + standard tools
Answer0:0
Workflow
Excel to tabularGalaxy UDTUnivariateSciPy
Total tokens
4.46M
Output
29.1K
Codex GPT-5.6 Luna

replicate 2

passUDT + standard tools
Answer0:0
Workflow
Excel to tabularFilter TabularRemove headermore stepsGalaxy UDTmean summary
Total tokens
5.12M
Output
31.6K
Codex GPT-5.6 Luna

replicate 3

passUDT + standard tools
Answer0:0
Workflow
Excel to tabularUnivariateGalaxy UDT
Total tokens
4.33M
Output
29.1K

DeepSeek V4 Pro via Codex

3 primary replicates
DeepSeek V4 Pro via Codex

replicate 1

failUDT + standard tools

Evaluation status

Manual review pendingThe evaluator marked this answer incorrect. The answer, workflow summary, usage, and available run records are linked, but a manual root-cause audit has not yet been added.
Answer1:0
Workflow
Excel to tabularGalaxy UDTSciPymore stepst-testSpearman correlation
Total tokens
13.42M
Output
78.5K
DeepSeek V4 Pro via Codex

replicate 2

passUDT + standard tools
Answer0:0
Workflow
Excel to tabularGalaxy UDTUnivariatestatsmodelsSciPy
Total tokens
3.15M
Output
25.4K
DeepSeek V4 Pro via Codex

replicate 3

failUDT + standard tools

Evaluation status

Manual review pendingThe evaluator marked this answer incorrect. The answer, workflow summary, usage, and available run records are linked, but a manual root-cause audit has not yet been added.
Answer1:0
Workflow
Excel to tabularGalaxy UDTmean summary
Total tokens
5.17M
Output
31.9K

DeepSeek V4 Pro via Claude CodeSuperseded

3 primary replicates
DeepSeek V4 Pro via Claude Code

replicate 1

passUDT + standard tools
Answer0:0
Workflow
Excel to tabularSciPyt-testmean summary
Total tokens
3.77M
Output
42.6K
DeepSeek V4 Pro via Claude Code

replicate 2

passUDT + standard tools
Answer0:0
Workflow
UnivariateGalaxy UDTt-test
Total tokens
1.58M
Output
17.6K
DeepSeek V4 Pro via Claude Code

replicate 3

passUDT + standard tools
Answer0:0
Workflow
UnivariateGalaxy UDTmean summary
Total tokens
2.80M
Output
33.0K

Execution condition

Open-ended code with skills

Codex GPT-5.5

3 primary replicates
Codex GPT-5.5

replicate 1

pass
Answer0:0
Workflow
Local analysisSciPystatsmodels
Total tokens
285.6K
Output
4.5K
Codex GPT-5.5

replicate 2

pass
Answer0:0
Workflow
Local analysisSciPystatsmodels
Total tokens
286.2K
Output
6.6K
Codex GPT-5.5

replicate 3

fail

Why it missed

Unstated paper workflow addedThis run inferred the source paper from a filename and added sample exclusions, mean-Ct normalization, and a Student t-test that the supplied task does not request. Those extra decisions changed 0:0 to 1:0.
Answer1:0
Workflow
Local analysisSciPystatsmodels
Total tokens
324.2K
Output
7.7K

Codex GPT-5.6 Sol

3 primary replicates
Codex GPT-5.6 Sol

replicate 1

fail

Why it missed

Unstated paper workflow addedThis run inferred the source-paper workflow and added sample exclusions, mean-Ct normalization, and a Student t-test that the self-contained task does not request. Those extra decisions changed the direct supplied-data result from 0:0 to 1:0.
Answer1:0
Workflow
Local analysis
Total tokens
721.6K
Output
6.4K
Codex GPT-5.6 Sol

replicate 2

fail

Why it missed

Unstated paper workflow addedThis run inferred the source-paper workflow and added sample exclusions, mean-Ct normalization, and a Student t-test that the self-contained task does not request. Those extra decisions changed the direct supplied-data result from 0:0 to 1:0.
Answer1:0
Workflow
Local analysis
Total tokens
400.6K
Output
5.4K
Codex GPT-5.6 Sol

replicate 3

fail

Why it missed

Unstated paper workflow addedThis run inferred the source-paper workflow and added sample exclusions, mean-Ct normalization, and a Student t-test that the self-contained task does not request. Those extra decisions changed the direct supplied-data result from 0:0 to 1:0.
Answer1:0
Workflow
Local analysis
Total tokens
548.2K
Output
7.1K

Codex GPT-5.6 Luna

3 primary replicates
Codex GPT-5.6 Luna

replicate 1

pass
Answer0:0
Workflow
Local analysis
Total tokens
637.8K
Output
10.0K
Codex GPT-5.6 Luna

replicate 2

pass
Answer0:0
Workflow
Local analysis
Total tokens
742.7K
Output
14.2K
Codex GPT-5.6 Luna

replicate 3

fail

Why it missed

Unstated paper workflow addedThis run reconstructed source-paper preprocessing instead of answering the supplied-data question directly. The extra exclusions and normalization changed the accepted 0:0 result to 1:0.
Answer1:0
Workflow
Local analysis
Total tokens
3.40M
Output
30.9K

DeepSeek V4 Pro via Codex

3 primary replicates
DeepSeek V4 Pro via Codex

replicate 1

fail

Evaluation status

Manual review pendingThe evaluator marked this answer incorrect. The answer, workflow summary, usage, and available run records are linked, but a manual root-cause audit has not yet been added.
Answer1:0
Workflow
Local analysisSciPystatsmodelst-testmean summary
Total tokens
1.38M
Output
14.3K
DeepSeek V4 Pro via Codex

replicate 2

fail

Evaluation status

Manual review pendingThe evaluator marked this answer incorrect. The answer, workflow summary, usage, and available run records are linked, but a manual root-cause audit has not yet been added.
Answer1:0
Workflow
Local analysisSciPystatsmodelsmean summaryt-test
Total tokens
2.59M
Output
28.2K
DeepSeek V4 Pro via Codex

replicate 3

fail

Evaluation status

Manual review pendingThe evaluator marked this answer incorrect. The answer, workflow summary, usage, and available run records are linked, but a manual root-cause audit has not yet been added.
Answer1:0
Workflow
Local analysisstatsmodelsSciPyt-testmean summary
Total tokens
574.0K
Output
13.5K

DeepSeek V4 Pro via Claude CodeSuperseded

3 primary replicates
DeepSeek V4 Pro via Claude Code

replicate 1

pass
Answer0:0
Workflow
Local analysisSciPyt-test
Total tokens
463.3K
Output
10.7K
DeepSeek V4 Pro via Claude Code

replicate 2

fail

Why it missed

Unstated paper workflow addedThis run reconstructed source-paper preprocessing instead of answering the self-contained data question. Excluding two samples and adding mean-Ct normalization changed 0:0 to 1:0.
Answer1:0
Workflow
Local analysisSciPyt-testmean summary
Total tokens
889.5K
Output
17.7K
DeepSeek V4 Pro via Claude Code

replicate 3

pass
Answer0:0
Workflow
Local analysisSciPystatsmodelst-testMann-Whitney Umedian summary
Total tokens
437.3K
Output
8.9K

bix-30-q3 · October 2026 · three additional replicates

GPT-5.6 Sol · token optimization

Galaxy-API code, high reasoning, Fast service. Previous runs are retained above.

Open-ended code averaged 0.56M tokens; previous website Galaxy averaged 3.14M; the new Galaxy runs averaged 1.44M, or 2.59× Open-ended code. Each mean covers three replicates of this same task with GPT-5.6 Sol.

Cached input is already included in input tokens. Full nested tool/job evidence is in each HF run's galaxy_execution_records.tar.gz, with an accompanying member index.

Optimization overview and all 150 runs