BixBench current item

bix-22-q1

Question

After calculating Pearson correlations between gene length and average gene expression levels for protein-coding genes, in which immune cell type (CD4, CD8, CD14, or CD19) is the correlation the weakest (lowest absolute correlation value)?

Accepted answer
CD14
Domain
general

Comparison

Pass counts and token totals across the same three replicates.

AgentGalaxy-API codeOpen-ended code
Codex GPT-5.53/3
replicate 1 replicate 2 replicate 3
3.35M total
3/3
replicate 1 replicate 2 replicate 3
415.0K total
Codex GPT-5.6 Sol3/3
replicate 1 replicate 2 replicate 3
2.22M total
3/3
replicate 1 replicate 2 replicate 3
573.8K total
Codex GPT-5.6 Luna3/3
replicate 1 replicate 2 replicate 3
11.49M total
3/3
replicate 1 replicate 2 replicate 3
547.1K total
DeepSeek V4 Pro via Codex3/3
replicate 1 replicate 2 replicate 3
32.47M total
3/3
replicate 1 replicate 2 replicate 3
1.85M total
DeepSeek V4 Pro via Claude Codesuperseded2/3
replicate 1 replicate 2 replicate 3
15.28M total
3/3
replicate 1 replicate 2 replicate 3
1.01M total

Execution condition

Galaxy-API code with skills

Codex GPT-5.5

3 primary replicates
Codex GPT-5.5

replicate 1

passUDT-only
AnswerCD14
Workflow
Galaxy UDTPearson correlation
Total tokens
572.5K
Output
6.2K
Codex GPT-5.5

replicate 2

passUDT-only
AnswerCD14
Workflow
Galaxy UDTPearson correlationSciPymean summary
Total tokens
899.9K
Output
11.4K
Codex GPT-5.5

replicate 3

passUDT-only
AnswerCD14
Workflow
Galaxy UDTSciPymean summaryPearson correlation
Total tokens
1.87M
Output
10.2K

Codex GPT-5.6 Sol

3 primary replicates
Codex GPT-5.6 Sol

replicate 1

passUDT-only
AnswerCD14
Workflow
Galaxy UDTPearson correlationSciPymean summary
Total tokens
805.1K
Output
11.3K
Codex GPT-5.6 Sol

replicate 2

passUDT-only
AnswerCD14
Workflow
Galaxy UDTPearson correlation
Total tokens
734.0K
Output
8.5K
Codex GPT-5.6 Sol

replicate 3

passUDT-only
AnswerCD14
Workflow
Galaxy UDTPearson correlation
Total tokens
676.0K
Output
6.1K

Codex GPT-5.6 Luna

3 primary replicates
Codex GPT-5.6 Luna

replicate 1

passUDT + standard tools
AnswerCD14
Workflow
Convert Characters1Csv To TabularFilter Tabularmore stepsSciPymean summary
Total tokens
5.08M
Output
29.8K
Codex GPT-5.6 Luna

replicate 2

passUDT + standard tools
AnswerCD14
Workflow
Datamash TransposeDatamash summaryGalaxy UDTSciPyPearson correlation
Total tokens
5.14M
Output
35.9K
Codex GPT-5.6 Luna

replicate 3

passUDT-only
AnswerCD14
Workflow
Galaxy UDTSciPyPearson correlationmean summary
Total tokens
1.27M
Output
15.5K

DeepSeek V4 Pro via Codex

3 primary replicates
DeepSeek V4 Pro via Codex

replicate 1

pass
AnswerCD14
Workflow
Pearson correlationTable ComputeAdd derived columnmore stepsMerge columnsShow Beginning1
Total tokens
13.92M
Output
62.7K
DeepSeek V4 Pro via Codex

replicate 2

pass
AnswerCD14
Workflow
Table ComputeDatamash TransposeDatamash summarymore stepsMatch rowsSelect columns
Total tokens
10.70M
Output
51.2K
DeepSeek V4 Pro via Codex

replicate 3

pass
AnswerCD14
Workflow
Csv To TabularSelect columnsMeltmore stepsTp Easyjoin ToolPearson correlation
Total tokens
7.85M
Output
45.6K

DeepSeek V4 Pro via Claude CodeSuperseded

3 primary replicates
DeepSeek V4 Pro via Claude Code

replicate 1

fail

Why it missed

Question interpretation errorThis run treated 'weakest' as the most negative signed Pearson correlation and selected CD4. The question asks for the lowest absolute correlation, meaning closest to zero, which is CD14.
AnswerCD4
Workflow
Tp Head ToolConvert Characters1Filter Tabularmore stepsJoin datasetsPearson correlation
Total tokens
6.57M
Output
53.2K
DeepSeek V4 Pro via Claude Code

replicate 2

pass
AnswerCD14
Workflow
Csv To TabularFilter TabularMatch rowsmore stepsMerge columnsPearson correlation
Total tokens
7.23M
Output
63.2K
DeepSeek V4 Pro via Claude Code

replicate 3

passUDT-only
AnswerCD14
Workflow
Galaxy UDTPearson correlationSciPymean summary
Total tokens
1.48M
Output
19.1K

Execution condition

Open-ended code with skills

Codex GPT-5.5

3 primary replicates
Codex GPT-5.5

replicate 1

pass
AnswerCD14
Workflow
Local analysisPearson correlation
Total tokens
128.7K
Output
3.0K
Codex GPT-5.5

replicate 2

pass
AnswerCD14
Workflow
Local analysisSciPyPearson correlation
Total tokens
109.0K
Output
2.9K
Codex GPT-5.5

replicate 3

pass
AnswerCD14
Workflow
Local analysisPearson correlation
Total tokens
177.3K
Output
3.6K

Codex GPT-5.6 Sol

3 primary replicates
Codex GPT-5.6 Sol

replicate 1

pass
AnswerCD14
Workflow
Local analysis
Total tokens
261.3K
Output
4.2K
Codex GPT-5.6 Sol

replicate 2

pass
AnswerCD14
Workflow
Local analysis
Total tokens
145.3K
Output
4.1K
Codex GPT-5.6 Sol

replicate 3

pass
AnswerCD14
Workflow
Local analysis
Total tokens
167.2K
Output
3.8K

Codex GPT-5.6 Luna

3 primary replicates
Codex GPT-5.6 Luna

replicate 1

pass
AnswerCD14
Workflow
Local analysis
Total tokens
157.0K
Output
4.8K
Codex GPT-5.6 Luna

replicate 2

pass
AnswerCD14
Workflow
Local analysis
Total tokens
204.5K
Output
5.6K
Codex GPT-5.6 Luna

replicate 3

pass
AnswerCD14
Workflow
Local analysis
Total tokens
185.6K
Output
5.6K

DeepSeek V4 Pro via Codex

3 primary replicates
DeepSeek V4 Pro via Codex

replicate 1

pass
AnswerCD14
Workflow
Local analysisSciPyPearson correlationmean summarymedian summary
Total tokens
624.1K
Output
9.0K
DeepSeek V4 Pro via Codex

replicate 2

pass
AnswerCD14
Workflow
Local analysismean summarySpearman correlationSciPymedian summary
Total tokens
544.1K
Output
9.0K
DeepSeek V4 Pro via Codex

replicate 3

pass
AnswerCD14
Workflow
Local analysisSciPyscikit-learnPearson correlationmean summary
Total tokens
681.1K
Output
13.3K

DeepSeek V4 Pro via Claude CodeSuperseded

3 primary replicates
DeepSeek V4 Pro via Claude Code

replicate 1

pass
AnswerCD14
Workflow
Local analysisSciPyPearson correlationmean summary
Total tokens
497.8K
Output
4.7K
DeepSeek V4 Pro via Claude Code

replicate 2

pass
AnswerCD14
Workflow
Local analysisSciPyPearson correlationmean summary
Total tokens
274.2K
Output
3.1K
DeepSeek V4 Pro via Claude Code

replicate 3

pass
AnswerCD14
Workflow
Local analysisSciPyPearson correlationmean summary
Total tokens
233.6K
Output
3.0K

bix-22-q1 · October 2026 · three additional replicates

GPT-5.6 Sol · token optimization

Galaxy-API code, high reasoning, Fast service. Previous runs are retained above.

Open-ended code averaged 0.19M tokens; previous website Galaxy averaged 0.74M; the new Galaxy runs averaged 0.63M, or 3.29× Open-ended code. Each mean covers three replicates of this same task with GPT-5.6 Sol.

Cached input is already included in input tokens. Full nested tool/job evidence is in each HF run's galaxy_execution_records.tar.gz, with an accompanying member index.

Optimization overview and all 150 runs