saluki-setup-optimize-q1

Question

Set up the Saluki model detailed in https://doi.org/10.1186/s13059-022-02811-x and use it to optimize the 3' UTR of the mRNA sequence GCCGCCACCATGGTGAGCAAGGGCGAGTAGTGTACATAATAAGGACT. Specifically, perform 3 rounds of directed evolution, trying every possible substitution in the 3' UTR and choosing the best after each round. Always use the average of predictions across all folds and use only the human output. Make sure to use GPUs if available. Report the full sequence of the optimized mRNA.

Inferred answer

GCCGCCACCATGGTGAGCAAGGGCGAGTAGTATAAATAATAAGGGCTUniquely inferred from submitted scores.

Domain

Machine Learning

Question style

Tooling

An answer can be uniquely inferred for 54 of 100 questions from submitted scores. Green: correct · Red: incorrect. For questions without a uniquely determined answer: Blue: matches prediction · Orange: differs from prediction. These are inferred answer checks, not official per-question grades.