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CompBioBench item

reverse-encode-q1

Question

For an ENCODE DNase-seq experiment, I started from the filtered BAM produced by the ENCODE4 v3.0.0-alpha.2 (GRCh38/hg38) pipeline. If the experiment had multiple replicates, I pooled all replicate BAMs by concatenating reads (i.e., merged at the read level) before downstream processing. I then applied an additional mapping-quality filter MAPQ ≥ 30, converted alignments to BED using bedtools bamToBed, and computed read counts in fixed 10 kb hg38 genomic bins. I then normalized the counts to sum to 1e6. The resulting binned track for one experiment is reverse.encode.q1.tsv.gz, but I lost the ENCODE experiment accession. Identify the originating ENCODE experiment accession (format ENCSR…) from which this file was derived.

Inferred answer
ENCSR597URKUniquely inferred from submitted scores.
Domain
Epigenomics
Question style
Metadata Recovery

An answer can be uniquely inferred for 54 of 100 questions from submitted scores. Green: correct · Red: incorrect. For questions without a uniquely determined answer: Blue: matches prediction · Orange: differs from prediction. These are inferred answer checks, not official per-question grades.

Galaxy

12/12 terminal item results

UDT = user-defined tool: custom code executed by Galaxy. Route badges summarize analysis tools, excluding uploads and automatic conversions. How usage is counted.

Codex GPT-5.5

3 replicates
Codex GPT-5.5

Replicate 1

CorrectUDT-only
AnswerENCSR597URK
Workflow
Q1 Track SummaryQ1 QuantizationQ1 ENCODE QC RankQ1 Direct BAM CompareQ1 Peak Screen1 more tools
Codex GPT-5.5

Replicate 2

RerunIncorrectUDT-only
AnswerENCSR396ZIN
Workflow
track_fingerprint_q1_v2score_encode4_dnase_bigwigs_v1score_encode4_dnase_bigwigs_v2score_encode4_dnase_bigwigs_s3_v1verify_encsr000epk_bam_v16 more tools
Total tokens
5.7M
Output
33.2K
Codex GPT-5.5

Replicate 3

CorrectUDT-only
AnswerENCSR597URK
Workflow
Q1 track diagnosticsQ1 track diagnostics v2Q1 track diagnostics v3Q1 track diagnostics v4Q1 UDT path probe11 more tools
Total tokens
5.0M
Output
35.8K

Codex GPT-5.6 Sol

3 replicates
Codex GPT-5.6 Sol

Replicate 1

CorrectUDT + standard tools
AnswerENCSR597URK
Workflow
Extract ENCODE alpha2 candidate filesSummarize normalized 10kb trackExtract ENCODE alpha2 read depthsInfer exact read count from normalized trackRank ENCODE alpha2 analyses by read depth15 more tools
Total tokens
41.0M
Output
60.2K
Codex GPT-5.6 Sol

Replicate 2

CorrectUDT-only
AnswerENCSR597URK
Workflow
Track quantization diagnosticNarrow ENCODE candidates by integer depthCompare ENCODE signal candidatesValidate ENCODE BAM against normalized binsRevise ENCODE shortlist after BAM validation2 more tools
Total tokens
24.8M
Output
44.9K
Codex GPT-5.6 Sol

Replicate 3

CorrectUDT-only
AnswerENCSR597URK
Workflow
DNase track inverse-normalization diagnosticFilter ENCODE DNase metadata for source pipelineProbe ENCODE remote bigWig summariesProbe ENCODE public-S3 bigWig summariesLink ENCODE filtered BAMs to normalized bigWigs8 more tools
Total tokens
14.3M
Output
35.5K

Codex + DeepSeek-v4-pro-0813

3 replicates
Codex + DeepSeek-v4-pro-0813

Replicate 1

CorrectUDT-only
AnswerENCSR597URK
Workflow
Arch ProbeReverse Encode BigWig RankSamtoolsBedtoolsReverse Encode BAM Verify2 more tools
Total tokens
16.7M
Output
82.5K
Codex + DeepSeek-v4-pro-0813

Replicate 2

RerunCorrectUDT-only
AnswerENCSR597URK
Workflow
User-defined tool
Total tokens
11.3M
Output
74.9K
Codex + DeepSeek-v4-pro-0813

Replicate 3

RerunCorrectUDT + standard tools
AnswerENCSR597URK
Workflow
Grouping1 → deeptools multi bigwig summary → User-defined tool → samtools view → bedtools bamtobed → bedtools intersectbed
Total tokens
13.2M
Output
51.5K

Codex GPT-5.6 Luna

3 replicates
Codex GPT-5.6 Luna

Replicate 1

CorrectUDT + standard tools
AnswerENCSR597URK
Workflow
Target Track DiagnosticTarget Copy ProbeUDT Render ProbeUdt Render Probe V67368A31D 9F3B 47E3 9059 2445Dfba6Bf414 more tools
Total tokens
66.6M
Output
216.0K
Codex GPT-5.6 Luna

Replicate 2

CorrectUDT + standard tools
AnswerENCSR597URK
Workflow
Datamash OpsENCODE comparison runtime probeENCODE BigWig source probeENCODE peak overlap probeENCODE peak candidate scan11 more tools
Total tokens
19.1M
Output
76.9K
Codex GPT-5.6 Luna

Replicate 3

CorrectUDT + standard tools
AnswerENCSR597URK
Workflow
Datamash OpsTable ComputeTp Head ToolTarget diagnosticsTarget diagnostics refined10 more tools
Total tokens
33.5M
Output
106.0K

Anycode

13/13 terminal item results

Codex GPT-5.5

3 replicates
Codex GPT-5.5

Replicate 1

Correct
AnswerENCSR597URK
Workflow
Local codePythonBedtoolsSamtools
Codex GPT-5.5

Replicate 2

Correct
AnswerENCSR597URK
Workflow
Local codePythonSamtoolsBedtoolspysam
Codex GPT-5.5

Replicate 3

Correct
AnswerENCSR597URK
Workflow
Local codePythonSamtoolsBedtools

Codex GPT-5.6 Sol

3 replicates
Codex GPT-5.6 Sol

Replicate 1

Correct
AnswerENCSR597URK
Workflow
Local codePythonSamtoolsSciPyBedtools
Codex GPT-5.6 Sol

Replicate 2

Correct
AnswerENCSR597URK
Workflow
Local codePythonSamtoolsBedtools
Codex GPT-5.6 Sol

Replicate 3

Correct
AnswerENCSR597URK
Workflow
Local codePythonSamtoolsBedtoolspysam

Codex + DeepSeek-v4-pro-0813

3 replicates
Codex + DeepSeek-v4-pro-0813

Replicate 1

Correct
AnswerENCSR597URK
Workflow
Local codePythonSamtoolspysamSciPy1 more tools
Total tokens
12.6M
Output
44.3K
Codex + DeepSeek-v4-pro-0813

Replicate 2

Correct
AnswerENCSR597URK
Workflow
Local codePythonSamtoolsBedtoolspysam
Total tokens
25.6M
Output
74.2K
Codex + DeepSeek-v4-pro-0813

Replicate 3

Correct
AnswerENCSR597URK
Workflow
Local codePythonSamtoolsBedtoolsSciPy
Total tokens
20.1M
Output
80.3K

Codex GPT-5.6 Luna

3 replicates
Codex GPT-5.6 Luna

Replicate 1

Correct
AnswerENCSR597URK
Workflow
Local codePythonSamtoolsBedtoolsSciPy
Codex GPT-5.6 Luna

Replicate 2

Correct
AnswerENCSR597URK
Workflow
Local codePythonSamtoolsBedtoolspysam
Codex GPT-5.6 Luna

Replicate 3

Correct
AnswerENCSR597URK
Workflow
Local codePythonSamtoolsBedtoolspysam

Codex GPT-6 Astra

1 replicate
Codex GPT-6 Astra

Replicate 1

Correct
AnswerENCSR597URK
Workflow
Local codePythonSciPypysamSamtools
Total tokens
907.0K
Output
8.3K