Question
I have a histone ChIP-seq ENCODE-style filtered tagAlign file (histone.chip.q1.signal.tagalign.gz) along with its control (histone.chip.q1.control.tagalign.gz), both hg38. I lost the metadata. Can you figure out the histone mark? Output exactly one label from this set: H3K4me3, H3K27ac, H3K4me1, H3K36me3, H3K27me3, H3K9me3.
- Inferred answer
H3K9me3Uniquely inferred from submitted scores.
- Domain
- Epigenomics
- Question style
- Metadata Recovery
An answer can be uniquely inferred for 54 of 100 questions from submitted scores. Green: correct · Red: incorrect. For questions without a uniquely determined answer: Blue: matches prediction · Orange: differs from prediction. These are inferred answer checks, not official per-question grades.
Galaxy
12/12 terminal item results
UDT = user-defined tool: custom code executed by Galaxy. Route badges summarize analysis tools, excluding uploads and automatic conversions. How usage is counted.
Codex GPT-5.5
3 replicates
Codex GPT-5.5
Replicate 1
CorrectUDT-only
AnswerH3K9me3
WorkflowHistone mark diagnostic→Histone mark diagnostic full→Histone mark repeat context→Histone mark final label
- Total tokens
- 935.8K
- Output
- 16.5K
Codex GPT-5.5
Replicate 2
CorrectUDT + standard tools
AnswerH3K9me3
WorkflowHistone mark diagnostic chr1 chr2→UDT render probe→UDT render probe command→Wc Gnu→Grep→2 more tools
- Total tokens
- 2.3M
- Output
- 23.1K
Codex GPT-5.5
Replicate 3
CorrectUDT + standard tools
AnswerH3K9me3
WorkflowChIP Histone Mark Diagnostic→ChIP Histone Mark Diagnostic 2→ChIP Histone Mark Diagnostic 3→ChIP Histone Mark Diagnostic 4→Macs2 Callpeak→3 more tools
- Total tokens
- 3.3M
- Output
- 23.6K
Codex GPT-5.6 Sol
3 replicates
Codex GPT-5.6 Sol
Replicate 1
CorrectUDT-only
AnswerH3K9me3
WorkflowHistone chr1 multiscale diagnostic→Histone chr1 RefSeq profile→Histone mark final classification
- Total tokens
- 1.5M
- Output
- 13.5K
Codex GPT-5.6 Sol
Replicate 2
CorrectUDT-only
AnswerH3K9me3
WorkflowTagAlign content probe q1→hg38 histone signature diagnostics q1→Validated histone mark label q1
- Total tokens
- 5.1M
- Output
- 20.9K
Codex GPT-5.6 Sol
Replicate 3
CorrectUDT-only
AnswerH3K9me3
WorkflowChr1 histone mark diagnostic→Genome-wide broad repressive histone diagnostic→Validate broad domains against UCSC hg38 centromeres→Validate broad domains against UCSC hg38 acen cytobands→Final evidence-gated histone mark label
- Total tokens
- 3.2M
- Output
- 19.6K
Codex + DeepSeek-v4-pro-0813
3 replicates
Codex + DeepSeek-v4-pro-0813
Replicate 1
IncorrectStandard tools only
AnswerH3K4me1
WorkflowMacs2 Callpeak→Chipseeker→Datamash Ops→Add A Column1→Bedtools Bedtobam→6 more tools
- Total tokens
- 19.4M
- Output
- 73.3K
Codex + DeepSeek-v4-pro-0813
Replicate 2
RerunIncorrectStandard tools only
AnswerH3K27ac
Workflowmacs2 callpeak → chipseeker → Count1 → Add a column1 → Summary Statistics1
- Total tokens
- 12.6M
- Output
- 45.3K
Codex + DeepSeek-v4-pro-0813
Replicate 3
IncorrectStandard tools only
AnswerH3K4me1
WorkflowMacs2 Callpeak→Chipseeker→Datamash Ops→Group and aggregate→Count1→11 more tools
- Total tokens
- 11.0M
- Output
- 46.7K
Codex GPT-5.6 Luna
3 replicates
Codex GPT-5.6 Luna
Replicate 1
CorrectUDT + standard tools
AnswerH3K9me3
WorkflowTagAlign distribution diagnostic→TagAlign keyed-bin diagnostic→Macs2 Callpeak→MACS2 peak summary→MACS2 broad peak summary→18 more tools
- Total tokens
- 22.6M
- Output
- 103.5K
Codex GPT-5.6 Luna
Replicate 2
CorrectUDT + standard tools
AnswerH3K9me3
WorkflowMacs2 Randsample→Macs2 Callpeak→TagAlign diagnostic→TagAlign gene profile→TagAlign repeat profile→1 more tools
Codex GPT-5.6 Luna
Replicate 3
CorrectUDT + standard tools
AnswerH3K9me3
WorkflowUpload1→Macs2 Callpeak→Histone ChIP-seq mark diagnostics→Chipseeker→Datamash Ops→11 more tools
- Total tokens
- 18.9M
- Output
- 73.9K