genome-coords-q1

Question

You are given a dataset (single_cell_dynamics_question.csv) of time-resolved single-cell measurements from 600 cells, each tracked over 250 consecutive time points. Each row corresponds to one cell at one time point and includes: enhancer coordinates: enh_x, enh_y, enh_z (nm), promoter coordinates: prom_x, prom_y, prom_z (nm), transcription - whether nascent transcription was detected at that time point (0/1). Define the enhancer-promoter distance as the 3D Euclidean distance. Define a proximity event (“contact”) deterministically as the distance <= 260nm. Based only on the quantities you computed above, select the single most defensible conclusion. Choose exactly one. A. Enhancer–promoter proximity and transcription are independent processes with no functional relationship. B. Transcriptional activity promotes enhancer–promoter proximity. C. Enhancer–promoter proximity promotes transcriptional activity. D. Contact and transcription share a feedback loop. E. An alternate explanation not covered here. Respond with a single letter (A-E).

Predicted answer

DMost likely answer for this question; not uniquely determined from submitted scores.

Domain

Epigenomics

Question style

Synthetic/Augmented Data

An answer can be uniquely inferred for 54 of 100 questions from submitted scores. Green: correct · Red: incorrect. For questions without a uniquely determined answer: Blue: matches prediction · Orange: differs from prediction. These are inferred answer checks, not official per-question grades.