find-amplification-q1

Question

You are given shallow paired-end whole-genome sequencing FASTQ files (find.amplification.R1.fq.gz, find.amplification.R2.fq.gz) simulated from a chromosome of the human genome (hg38) that contains a regional copy-number gain. Identify the approximate coordinates of the amplified region relative to the reference genome and the amplification factor, defined as the mean read-depth in the amplified region divided by the mean read-depth in flanking non-amplified regions. Report the chromosome, the start coordinate, and the end coordinate rounded to the nearest 100,000 bases, followed by a single comma and the amplification factor rounded to nearest multiple of 0.5. Format your answer as chr:start-end factor. For example: chr21:23000000-26000000,2.0

Predicted answer

chr22:36000000-36400000,1.5Most likely answer for this question; not uniquely determined from submitted scores.

Domain

Genomics

Question style

Synthetic/Augmented Data

An answer can be uniquely inferred for 54 of 100 questions from submitted scores. Green: correct · Red: incorrect. For questions without a uniquely determined answer: Blue: matches prediction · Orange: differs from prediction. These are inferred answer checks, not official per-question grades.